(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

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Chemical Name:(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one
CAS No.:110724-56-6
Molecular Formula:C₂₈H₂₆F₄O₄
Molecular Weight:502.506
Hs Code.:

Synonyms:(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

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Chemical Property of (4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

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Technology Process of (4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

There total 13 articles about (4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 110724-51-1
(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{2-[(4-fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-tetrahydro-pyran-2-one

: 110724-56-6
(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jm00114a004

Reference yield:

: 402-26-6
3-(trifluoromethyl)phenylmagnesium bromide

: 110724-56-6
(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

4: glacial acetic acid / tetrahydrofuran / 26 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

6: 79 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; Celite; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 110724-56-6
(4R,6S)-6-{2-[(4-Fluoro-phenyl)-(3-trifluoromethyl-phenyl)-methyl]-4,6-dimethyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

6: glacial acetic acid / tetrahydrofuran / 26 h / Heating

7: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

8: 79 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; aluminium trichloride; Celite; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; acetic acid; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00114a004