(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

Base Information

Chemical Name:(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate
CAS No.:187851-97-4
Molecular Formula:C₃₀H₃₈O₅Si
Molecular Weight:506.714
Hs Code.:

Synonyms:(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

Chemical Property:

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Technology Process of (4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

There total 4 articles about (4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 187851-96-3
(4-methoxyphenyl)methyl (R)-5,6-dihydroxyhexanoate

: 187851-97-4
(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1055/s-1998-2123

Reference yield:

: 187851-95-2
(4-methoxyphenyl)methyl hex-5-enoate

: 187851-97-4
(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-bis(dihydroquininyl)anthraquinone, K₃Fe(CN)6, K₂CO₃, NaHCO₃, potassium osmate(VI) dihydrate, H₂O / 2-methyl-propan-2-ol / 12 h / 0 °C

2: 91 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

With 1H-imidazole; potassium osmate(VI); 1,4-bis(dihydroquinidinyl)anthraquinone; water; sodium hydrogencarbonate; potassium carbonate; potassium hexacyanoferrate(III); In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1055/s-1998-2123

Reference yield:

: 1577-22-6
5-hexenoic acid

: 187851-97-4
(4-methoxyphenyl)methyl (R)-6-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaHCO₃ / dimethylformamide / 72 h / 45 °C

2: 51 percent / K₃Fe(CN)6, K₂CO₃, NaHCO₃, (DHQD)2-AQN, K₂OsO₂(OH)2 / 2-methyl-propan-2-ol / 48 h / 0 °C

3: 89 percent / imidazole / dimethylformamide / 15 h / 25 °C

With 1H-imidazole; (DHQD)2AQN; K₂OsO₂(OH)2; sodium hydrogencarbonate; potassium carbonate; potassium hexacyanoferrate(III); In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo962166h