(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Base Information

Chemical Name:(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester
CAS No.:883242-24-8
Molecular Formula:C₂₃H₂₃N₃O₁₀
Molecular Weight:501.45
Hs Code.:

Synonyms:(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

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Chemical Property of (2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

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Technology Process of (2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

There total 3 articles about (2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 59234-43-4
meso-1-((benzyloxy)carbonyl)piperidine-2,6-dicarboxylic acid

: 883242-24-8
(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethyl acetate; N,N-dimethyl-formamide; for 18h;
DOI:10.1021/jm051009k

Reference yield:

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: 883242-24-8
(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Rh/Al₂O₃ / aq. NaOH / 24 h / 20 °C / 2327.17 Torr

2: 36.9 g / aq. NaOH / 18 h / 20 °C

3: 78 percent / EDC / ethyl acetate; dimethylformamide / 18 h

With sodium hydroxide; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; Rh/Al₂O₃; In sodium hydroxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm051009k

Reference yield:

: 59234-40-1,429661-20-1
cis-meso-piperidine-2,6-dicarboxylic acid

: 883242-24-8
(2S,6R)-Piperidine-1,2,6-tricarboxylic acid benzyl ester bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 36.9 g / aq. NaOH / 18 h / 20 °C

2: 78 percent / EDC / ethyl acetate; dimethylformamide / 18 h

With sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm051009k