2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

Base Information

Chemical Name:2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl
CAS No.:947499-31-2
Molecular Formula:C₂₂H₂₀O₅
Molecular Weight:364.398
Hs Code.:

Synonyms:2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

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Chemical Property of 2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

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Technology Process of 2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

There total 2 articles about 2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 947499-30-1
2'-benzyloxy-3,5-dimethoxy-biphenyl-2-carbaldehyde

: 947499-31-2
2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

Guidance literature:: With sodium chlorite; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 23 ℃; for 6h;
DOI:10.1021/ja0736919

Reference yield:

: 81574-69-8
2-bromo-4,6-dimethoxybenzaldehyde

: 947499-31-2
2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / potassium carbonate / palladium tetrakistriphenylphosphine / dimethylformamide / 48 h / 80 °C

2: 87 percent / sodium chlorite; monobasic sodium phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 6 h / 23 °C

With sodium chlorite; 2-methyl-but-2-ene; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Suzuki coupling / 2: Pinnick oxidation;
DOI:10.1021/ja0736919

Reference yield: 83.0%

: 947499-31-2
2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl

: 74-88-4
methyl iodide

: 947499-35-6
2'-benzyloxy-3,5-dimethoxy-biphenyl-2-carboxylic acid metyl ester

Guidance literature:: 2'-benzyloxy-2-carboxy-3,5-dimethoxy-biphenyl; With N,N-diethyl-N-isopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; for 3h; Further stages.;
DOI:10.1021/ja0736919