Technology Process of 2'-benzyloxy-2-carbamide-3,5-dimethoxy-biphenyl
There total 5 articles about 2'-benzyloxy-2-carbamide-3,5-dimethoxy-biphenyl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium; ammonia;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
DOI:10.1021/ja0736919
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 66 percent / phosphoryl chloride / 6 h / 100 °C
2.1: 62 percent / potassium carbonate / palladium tetrakistriphenylphosphine / dimethylformamide / 48 h / 80 °C
3.1: 87 percent / sodium chlorite; monobasic sodium phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 6 h / 23 °C
4.1: diethylisopropylamine / dimethylformamide / 0.17 h / 20 °C
4.2: 83 percent / dimethylformamide / 3 h
5.1: 70 percent / ammonia; butyllithium / tetrahydrofuran / 1 h / -78 °C
With
sodium chlorite; n-butyllithium; 2-methyl-but-2-ene; N,N-diethyl-N-isopropylamine; ammonia; potassium carbonate; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2.1: Suzuki coupling / 3.1: Pinnick oxidation;
DOI:10.1021/ja0736919
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 62 percent / potassium carbonate / palladium tetrakistriphenylphosphine / dimethylformamide / 48 h / 80 °C
2.1: 87 percent / sodium chlorite; monobasic sodium phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 6 h / 23 °C
3.1: diethylisopropylamine / dimethylformamide / 0.17 h / 20 °C
3.2: 83 percent / dimethylformamide / 3 h
4.1: 70 percent / ammonia; butyllithium / tetrahydrofuran / 1 h / -78 °C
With
sodium chlorite; n-butyllithium; 2-methyl-but-2-ene; N,N-diethyl-N-isopropylamine; ammonia; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
1.1: Suzuki coupling / 2.1: Pinnick oxidation;
DOI:10.1021/ja0736919
