(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

Base Information

Chemical Name:(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol
CAS No.:637741-29-8
Molecular Formula:C₃₅H₅₀O₈Si
Molecular Weight:626.863
Hs Code.:

Synonyms:(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

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Chemical Property of (2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

Chemical Property:

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Technology Process of (2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

There total 3 articles about (2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 331625-80-0
(2S,3R,4R)-2,3,5-tris(4-methoxybenzyloxy)-1,4-pentanediol

: 637741-29-8
(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/b305818b

Reference yield:

: 541546-94-5,773896-71-2
allyl α,β-D-ribofuranoside

: 637741-29-8
(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium bromide; aq. KOH / tetrahydrofuran / 90 °C

2: diisobutylaluminum hydride / NiCl₂(dppp) / diethyl ether; hexane / 0 °C

3: 77 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; potassium hydroxide; tetrabutylammomium bromide; diisobutylaluminium hydride; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b305818b

Reference yield:

: 331625-54-8
allyl 2,3,5-tri-O-p-methoxybenzyl-D-ribofuranose

: 637741-29-8
(2R,3R,4S)-1,3,4-tris(4-methoxybenzyloxy)-5-(tert-butyldimethylsiloxy)-2-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminum hydride / NiCl₂(dppp) / diethyl ether; hexane / 0 °C

2: 77 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; diisobutylaluminium hydride; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b305818b