3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

Base Information

Chemical Name:3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole
CAS No.:134425-20-0
Molecular Formula:C₂₇H₂₅ClN₄O₂S
Molecular Weight:505.04
Hs Code.:

Synonyms:3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

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Chemical Property of 3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

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Technology Process of 3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

There total 6 articles about 3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 134425-19-7
3-n-butyl-5-<(4-chlorobenzyl)thio>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

: 134425-20-0
3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 2.5h;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 134425-20-0
3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / lithium azide / dimethylsulfoxide / 1 h / Ambient temperature

2: triphenylphosphine / 5.5 h / Ambient temperature

3: hydrazine hydrate / tetrahydrofuran / 0.17 h

4: 64 percent / 2-methoxy-ethanol / 4 h / Heating

5: 71 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / Ambient temperature

6: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2.5 h

With lithium azide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-91-2
4'-(azidomethyl)[1,1'-biphenyl]-2-carbonitrile

: 134425-20-0
3-n-butyl-5-<(4-chlorobenzyl)sulfonyl>-4-<(2'-cyanobiphenyl-4-yl)methyl>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / 5.5 h / Ambient temperature

2: hydrazine hydrate / tetrahydrofuran / 0.17 h

3: 64 percent / 2-methoxy-ethanol / 4 h / Heating

4: 71 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / Ambient temperature

5: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2.5 h

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2-methoxy-ethanol;
DOI:10.1021/jm00057a009