ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate
CAS No.:1442432-68-9
Molecular Formula:C₂₈H₃₇N₃O₃
Molecular Weight:463.62
Hs Code.:

Synonyms:ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

There total 5 articles about ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1442430-90-1
1-(cyclohexylmethyl)-4-(ethoxycarbonyl)-5-methyl-1H-pyrrol-2-ylboronic acid

: 1442432-67-8
3-bromo-N-tert-butylindolizine-1-carboxamide

: 1442432-68-9
ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane; water; at 85 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1442430-89-8
ethyl 1-(cyclohexylmethyl)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate

: 1442432-68-9
ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate; ammonium acetate; water / acetone / 48 h / Reflux

2: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; ammonium acetate; tetrabutylammomium bromide; water; potassium carbonate; In 1,4-dioxane; water; acetone;

Reference yield:

: 90347-97-0
indolizine-1-carboxylic acid

: 1442432-68-9
ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0.5 h

2.1: copper(II) bromide dihydrate / acetonitrile / 1.5 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(II) bromide dihydrate; tetrabutylammomium bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;