5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid
CAS No.:1442432-69-0
Molecular Formula:C₂₆H₃₃N₃O₃
Molecular Weight:435.566
Hs Code.:

Synonyms:5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

There total 7 articles about 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1442432-68-9
ethyl 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

: 1442432-69-0
5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: With potassium tert-butylate; water; In dimethyl sulfoxide; at 80 ℃;

Reference yield:

: 1442430-89-8
ethyl 1-(cyclohexylmethyl)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate

: 1442432-69-0
5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate; ammonium acetate; water / acetone / 48 h / Reflux

2: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

3: potassium tert-butylate; water / dimethyl sulfoxide / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; potassium tert-butylate; ammonium acetate; tetrabutylammomium bromide; water; potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; acetone;

Reference yield:

: 1442430-90-1
1-(cyclohexylmethyl)-4-(ethoxycarbonyl)-5-methyl-1H-pyrrol-2-ylboronic acid

: 1442432-69-0
5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

2: potassium tert-butylate; water / dimethyl sulfoxide / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; tetrabutylammomium bromide; water; potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide;