N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

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Chemical Name:N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide
CAS No.:1442425-19-5
Molecular Formula:C₃₁H₄₂N₄O₃
Molecular Weight:518.699
Hs Code.:

Synonyms:N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

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Chemical Property of N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

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Technology Process of N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

There total 8 articles about N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 38041-19-9
4-aminotetrahydropyran

: 1442432-69-0
5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid

: 1442425-19-5
N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

Guidance literature:: 5-(1-(tert-butylcarbamoyl)indolizin-3-yl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-aminotetrahydropyran; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 1442430-89-8
ethyl 1-(cyclohexylmethyl)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate

: 1442425-19-5
N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; ammonium acetate; water / acetone / 48 h / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

3.1: potassium tert-butylate; water / dimethyl sulfoxide / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 0.5 h

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; potassium tert-butylate; ammonium acetate; tetrabutylammomium bromide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1442430-90-1
1-(cyclohexylmethyl)-4-(ethoxycarbonyl)-5-methyl-1H-pyrrol-2-ylboronic acid

: 1442425-19-5
N-tert-butyl-3-(1-(cyclohexylmethyl)-5-methyl-4-(tetrahydro-2H-pyran-4-ylcarbamoyl)-1H-pyrrol-2-yl)indolizine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1 h / 85 °C / Microwave irradiation; Inert atmosphere

2.1: potassium tert-butylate; water / dimethyl sulfoxide / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 0.5 h

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; tetrabutylammomium bromide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;