4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

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Chemical Name:4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester
CAS No.:868083-08-3
Molecular Formula:C₂₃H₂₃NO₈
Molecular Weight:441.438
Hs Code.:

Synonyms:4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

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Chemical Property of 4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

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Technology Process of 4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

There total 4 articles about 4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 868082-98-8
[(S)-3-((R)-1-Hydroxy-ethyl)-4-oxo-azetidin-(2Z)-ylidene]-acetic acid benzyl ester

: 50597-60-9
3,5-dimethoxy-4-hydroxybenzoic acid chloride

: 868083-08-3
4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

Guidance literature:: With tin(IV) chloride; In benzene; for 4h; Heating;
DOI:10.1016/j.bmc.2005.06.041

Reference yield:

: 868082-96-6
[(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-(2Z)-ylidene]-acetic acid benzyl ester

: 868083-08-3
4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / acetonitrile

2: SnCl₄ / benzene; CH₂Cl₂ / 4 h / Heating

With hydrogenchloride; tin(IV) chloride; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/jm0580510

Reference yield:

: 86978-81-6
(3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-1-trimethylsilyl-2-azetidinone

: 868083-08-3
4-Hydroxy-3,5-dimethoxy-benzoic acid (R)-1-{(S)-2-[1-benzyloxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-3-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / TiCl₄ / CH₂Cl₂ / 0 - 20 °C

2: HCl / acetonitrile

3: SnCl₄ / benzene; CH₂Cl₂ / 4 h / Heating

With hydrogenchloride; titanium tetrachloride; tin(IV) chloride; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/jm0580510