(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

Base Information

Chemical Name:(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester
CAS No.:1403884-03-6
Molecular Formula:C₁₁H₁₁F₂NO₅
Molecular Weight:275.209
Hs Code.:

Synonyms:(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

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Chemical Property of (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

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Technology Process of (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

There total 3 articles about (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1403884-02-5
(R)-3-benzyloxy-2-(3-carbamoyl-2,4-difluoro-phenoxy)propionic acid methyl ester

: 1403884-03-6
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

Guidance literature:: With hydrogen; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; at 20 ℃; for 1h; under 760.051 Torr;

Reference yield:

: 2,6-difluoro-3-methoxybenzamide

: 1403884-03-6
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

3: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; boron tribromide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.11.002

Reference yield:

: 951122-37-5
2,6-difluoro-3-hydroxy-benzamide

: 1403884-03-6
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.11.002