but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

Base Information

Chemical Name:but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester
CAS No.:942062-98-8
Molecular Formula:C₂₁H₃₄O₃Si
Molecular Weight:362.585
Hs Code.:

Synonyms:but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

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Chemical Property of but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

Chemical Property:

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Technology Process of but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

There total 3 articles about but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 942062-97-7
4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butan-1-ol

: 623-68-7
trans-crotonic anhydride

: 942062-98-8
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ol0704901

Reference yield:

: 271769-81-4
(1,1-dimethylethyl)[(2-iodophenyl)methoxy]dimethylsilane

: 942062-98-8
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / tetra-n-butylammonium bromide; NaOAc; LiCl / Pd(OAc)2 / dimethylformamide / 72 h / 50 °C

2: 86 percent / NaBH₄ / tetrahydrofuran / 1 h

3: 70 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; sodium tetrahydroborate; tetrabutylammomium bromide; sodium acetate; triethylamine; lithium chloride; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0704901

Reference yield:

: 942062-96-6
4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyraldehyde

: 942062-98-8
but-2-enoic acid 4-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / NaBH₄ / tetrahydrofuran / 1 h

2: 70 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0704901