C₁₅H₂₀O₂S

Base Information

• Chemical Name: C₁₅H₂₀O₂S
• CAS No.: 1373398-07-2
• Molecular Formula: C₁₅H₂₀O₂S
• Molecular Weight: 264.389
• Mol file: 1373398-07-2.mol

Synonyms:C₁₅H₂₀O₂S

Chemical Property of C₁₅H₂₀O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₀O₂S

There total 6 articles about C₁₅H₂₀O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C15H18O2S (1373398-06-1) → C15H20O2S (1373398-07-2)

Guidance literature:

With methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; at -10 ℃; chemoselective reaction;

DOI:10.1021/ol3007698

Reference yield:

3-Methyl-4-phenylthio-2-butensaeure-ethylester (79597-59-4) → C15H20O2S (1373398-07-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.83 h / -78 °C / Inert atmosphere

2.1: (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / chloroform; N,N-dimethyl-formamide / 72 h

3.1: Jacobsen's catalyst / tert-butyl methyl ether / 0.08 h / -78 °C / Molecular sieve

3.2: 20 h / -78 - -30 °C

3.3: -78 - 20 °C

4.1: methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / -10 °C

With methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; Jacobsen's catalyst; (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; diisobutylaluminium hydride; In dichloromethane; tert-butyl methyl ether; chloroform; N,N-dimethyl-formamide; toluene; 3.2: Diels-Alder reaction / 4.1: Luche reduction;

DOI:10.1021/ol3007698

Reference yield:

1-(phenylsulfanyl)acetone (5042-53-5) → C15H20O2S (1373398-07-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / benzene / 12 h / Reflux

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.83 h / -78 °C / Inert atmosphere

3.1: (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / chloroform; N,N-dimethyl-formamide / 72 h

4.1: Jacobsen's catalyst / tert-butyl methyl ether / 0.08 h / -78 °C / Molecular sieve

4.2: 20 h / -78 - -30 °C

4.3: -78 - 20 °C

5.1: methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / -10 °C

With methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; Jacobsen's catalyst; (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; diisobutylaluminium hydride; triethylamine; In dichloromethane; tert-butyl methyl ether; chloroform; N,N-dimethyl-formamide; toluene; benzene; 4.2: Diels-Alder reaction / 5.1: Luche reduction;

DOI:10.1021/ol3007698

upstream raw materials:

C₁₅H₁₈O₂S

C₁₁H₁₄OS

1-(phenylsulfanyl)acetone

3-Methyl-4-phenylthio-2-butensaeure-ethylester

Downstream raw materials:

C₁₈H₂₄O₃S

C₁₇H₂₂O₃S

C₂₃H₃₈O₄SSi

C₂₃H₃₈O₂SSi