(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

Base Information

Chemical Name:(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol
CAS No.:889893-53-2
Molecular Formula:C₁₇H₂₇NO₃Si
Molecular Weight:321.492
Hs Code.:

Synonyms:(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

Chemical Property:

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Technology Process of (S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

There total 4 articles about (S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: ((S)-(-)-(4-tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methyl 4-methylbenzene sulfonate

: 889893-53-2
(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 12h;
DOI:10.1002/asia.201901742

Reference yield:

: 62203-32-1
2-phenyl-4(bis-hydroxymethyl)-Δ²-oxazoline

: 889893-53-2
(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: Pseudomonas fluorescens lipase

2: 100 percent / imidazole / dimethylformamide / 1 h / 20 °C

3: 98 percent / potassium carbonate / methanol / 0.17 h / 20 °C

With 1H-imidazole; pseudomonas fluorescens lipase; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.022

Reference yield:

: 98-88-4
benzoyl chloride

: 889893-53-2
(S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); copper(II) bis(trifluoromethanesulfonate); sodium carbonate / acetonitrile / 15 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

4: lithium aluminium tetrahydride / diethyl ether / 12 h / 0 - 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; copper(II) bis(trifluoromethanesulfonate); sodium carbonate; triethylamine; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/asia.201901742