(2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone

Base Information

• Chemical Name: (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone
• CAS No.: 145354-01-4
• Molecular Formula: C₁₈H₂₀O₇
• Molecular Weight: 348.353
• Mol file: 145354-01-4.mol

Synonyms:(2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone

Chemical Property of (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone

There total 5 articles about (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

bis(2,4,5-trimethoxyphenyl)methanone (110047-63-7) → (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone (145354-01-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201100715

Reference yield: 73.0%

1,2,4-trimethoxy-benzene (135-77-3) + 2,4,5-trimethoxybenzoyl chloride (42833-66-9) → (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone (145354-01-4)

Guidance literature:

With aluminium trichloride; In diethyl ether; for 8h; Ambient temperature;

DOI:10.1002/jps.2600811114

Reference yield:

[(bromodifluoromethyl)sulfanyl]benzene (78031-08-0) → (2-hydroxy-4,5-dimethoxyphenyl) (2',4',5'-trimethoxyphenyl)methanone (145354-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 16 h / 70 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere

With boron trifluoride diethyl etherate; boron tribromide; In dichloromethane; 1: Friedel Crafts type alkylation;

DOI:10.1002/ejoc.201100715

upstream raw materials:

1,2,4-trimethoxy-benzene

2,4,5-trimethoxybenzoyl chloride

asaronic acid

bis(2,4,5-trimethoxyphenyl)methanone