C₂₃H₃₁BrO₂Si

Base Information

Chemical Name:C₂₃H₃₁BrO₂Si
CAS No.:871355-14-5
Molecular Formula:C₂₃H₃₁BrO₂Si
Molecular Weight:447.487
Hs Code.:

C<sub>23</sub>H<sub>31</sub>BrO<sub>2</sub>Si

Synonyms:C₂₃H₃₁BrO₂Si

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Chemical Property of C₂₃H₃₁BrO₂Si

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Technology Process of C₂₃H₃₁BrO₂Si

There total 1 articles about C₂₃H₃₁BrO₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 871348-26-4
C₇H₁₃BrO₂

: 58479-61-1
tert-butylchlorodiphenylsilane

: 871355-14-5
C₂₃H₃₁BrO₂Si

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 15 ℃;
DOI:10.1055/s-0032-1317920

Reference yield: 43.0%

: 871355-14-5
C₂₃H₃₁BrO₂Si

: 871355-29-2
(S)-2-bromo-7-(tert-butyldiphenylsilanyloxy)-hept-1-en-4-ol

: 784194-08-7
(R)-2-bromo-7-(tert-butyldiphenylsilanyloxy)-hept-1-en-4-ol

Guidance literature:: With Chiralpak-OD; chemoselective reaction; Resolution of racemate;
DOI:10.1055/s-0032-1317920

Reference yield:

: 871355-14-5
C₂₃H₃₁BrO₂Si

: 253128-10-8
3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1: Chiralpak-OD / Resolution of racemate

2: triethylamine; dmap / dichloromethane / 20 °C

3: (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; nickel dichloride; chromium dichloride / tetrahydrofuran / 25 °C

4: silica gel / isopropyl alcohol / 25 °C

5: tetrahydrofuran / 0 °C

6: potassium hexamethylsilazane / toluene; tetrahydrofuran / -70 °C

7: hydrogenchloride / water; isopropyl alcohol / 15 °C

8: dmap; 2,4,6-trimethyl-pyridine / dichloromethane / 0 °C

9: triethylamine / tetrahydrofuran / 0 °C

10: (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methane sulfonamide; triethylamine; nickel dichloride; chromium dichloride / tetrahydrofuran / 25 °C / Inert atmosphere

11: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 °C

12: diisobutylaluminium hydride / toluene / -70 °C / Large scale

With 2,4,6-trimethyl-pyridine; chromium dichloride; hydrogenchloride; dmap; (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; silica gel; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; nickel dichloride; (S)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methane sulfonamide; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; 3: |Nozaki-Hiyama-Kishi Reaction / 10: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1055/s-0032-1317920