784194-08-7

Usage

Chiral molecule

3D arrangement of atoms is specific

Building block

Used in organic synthesis and research for creating more complex molecules

Bromine atom

Present in the chemical structure

Silyl ether functional group

Present in the chemical structure, makes it useful for various chemical reactions

Valuable for development

Pharmaceutical, agrochemical, and other fine chemicals industries

Specific stereochemistry

Makes the compound unique and valuable for various applications.

Upstream product

• 871355-14-5 C₂₃H₃₁BrO₂Si 
• 871355-29-2 (S)-2-bromo-7-(tert-butyldiphenylsilanyloxy)-hept-1-en-4-ol 
• 871348-26-4 C₇H₁₃BrO₂ 
• 127793-62-8 4-((tert-butyldiphenylsilyl)oxy)butanal 
• 513-31-5 2-bromoallyl bromide 

Downstream Products

• 871355-80-5 toluene-4-sulfonic acid 3-bromo-1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-but-3-enyl ester 
• 253128-10-8 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol 
• 1424343-98-5 C₄₆H₇₁NO₈SSi₂ 
• 871357-02-7 C₃₉H₆₃NO₅Si₂ 
• 1139773-92-4 C₃₉H₆₃NO₅Si₂ 
• 871357-66-3 C₂₃H₃₇F₃O₉S₂ 
• 1424343-99-6 C₅₁H₉₀O₁₃S₂Si₂ 
• 253128-09-5 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl) ethyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 

Relevant academic research and scientific papers

Process development of halaven: Synthesis of the C14-C35 fragment via iterative nozaki-hiyama-kishi reaction-williamson ether cyclization

Multikilogram manufacturing process of the Halaven C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment. Georg Thieme Verlag Stuttgart - New York.

Further improvement on sulfonamide-based ligand for catalytic asymmetric 2-haloallylation and allylation

(Chemical Equation Presented) The sulfonamide-based ligand B was found to exhibit an outstanding crystallinity and perform well as a ligand for Cr-mediated catalytic asymmetric 2-haloallylation and allylation. The new ligand has an appealing advantage ove

INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B

The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).

Fe/Cr- and Co/Cr-mediated catalytic asymmetric 2-haloallylations of aldehydes

The first example to couple aldehydes and 3-bromo-2-halopropenes in a catalytic asymmetric manner is reported. The coupling reaction is effected by the use of a chiral sulfonamide-Cr complex (prepared in situ from 1d, CrBr3, Fe(III) or from Co(II), Et3N, and Mn), TMSCl, and 2,6-lutidine. The method reported here is operationally simple and scalable, furnishing 3-halohomoallylic alcohols with a synthetically useful level of enantiomeric excess. Copyright

New catalytic cycle for couplings of aldehydes with organochromium reagents

(Chemical Equation Presented) A new catalytic cycle has been developed to effect all three subgroups of Cr-mediated couplings, i.e., (1) Ni/Cr-mediated alkenylation, alkynylation, and arylation, (2) Co/Cr-mediated 2-haloallylation, alkylation, and proparg