(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

Base Information

Chemical Name:(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester
CAS No.:1192176-43-4
Molecular Formula:C₂₈H₃₈F₂N₂O₄
Molecular Weight:504.618
Hs Code.:

Synonyms:(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

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Chemical Property of (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

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Technology Process of (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

There total 6 articles about (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride

: 1192176-42-3
8-(3,4-difluoro-benzyloxy)-octanoic acid

: 1192176-43-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

Guidance literature:: 8-(3,4-difluoro-benzyloxy)-octanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 1192176-43-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: dimethylsulfide borane complex / 0 - 20 °C / Reflux

2.2: 0 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 16 h / 20 °C

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 629-41-4
1,8-Octanediol

: 1192176-43-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 4 h

2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 16 h / 20 °C

With dipyridinium dichromate; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;