(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

Base Information

Chemical Name:(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester
CAS No.:1192595-54-2
Molecular Formula:C₁₈H₂₆N₂O₅
Molecular Weight:350.415
Hs Code.:

Synonyms:(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

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Chemical Property of (R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

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Technology Process of (R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

There total 1 articles about (R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 506-59-2
N,N-dimethylammonium chloride

: 1192595-54-2
(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

Guidance literature:: 4-benzyl Boc-D-aspartate; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 1h;

N,N-dimethylammonium chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 87.0%

: 1192595-54-2
(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

: (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride

Guidance literature:: (R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester; With dimethylsulfide borane complex; at 0 - 20 ℃; Reflux;

With hydrogenchloride; water; at 0 ℃;

Reference yield:

: 1192595-54-2
(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

: 1192177-66-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / 0 - 20 °C / Reflux

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 16 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / 0.5 h / 760.05 Torr

4.1: potassium hydrogencarbonate / methanol / 16 h / 20 °C

With dimethylsulfide borane complex; hydrogen; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;