(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Base Information

Chemical Name:(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate
CAS No.:1192177-66-4
Molecular Formula:C₂₂H₃₄F₂N₂O₄
Molecular Weight:428.52
Hs Code.:

Synonyms:(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Chemical Property:

Purity/Quality:

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Technology Process of (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

There total 8 articles about (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192176-40-1
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid

: 74-88-4
methyl iodide

: 1192177-66-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Guidance literature:: With potassium hydrogencarbonate; In methanol; at 20 ℃; for 16h;

Reference yield:

: 629-41-4
1,8-Octanediol

: 1192177-66-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 4 h

2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 16 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / 0.5 h / 760.05 Torr

5.1: potassium hydrogencarbonate / methanol / 16 h / 20 °C

With dipyridinium dichromate; hydrogen; sodium hydride; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1192595-54-2
(R)-3-tert-butoxycarbonylamino-N,N-dimethyl-succinamic acid benzyl ester

: 1192177-66-4
(R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / 0 - 20 °C / Reflux

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 16 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / 0.5 h / 760.05 Torr

4.1: potassium hydrogencarbonate / methanol / 16 h / 20 °C

With dimethylsulfide borane complex; hydrogen; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;