2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)-

Base Information

• Chemical Name: 2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)-
• CAS No.: 714273-84-4
• Molecular Formula: C₁₄H₁₈N₄O₃
• Molecular Weight: 290.322
• Mol file: 714273-84-4.mol

Synonyms:1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

Chemical Property of 2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)-

There total 2 articles about 2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N,N'-diacetylpiperazin-2,5-dione (3027-05-2) + 5-(tert-butyl)-1H-imidazole-4-carbaldehyde (714273-83-3) → 1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione (714273-84-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115435

Reference yield: 47.0%

4-tert-butyl-1H-imidazole-5-carbaldehyde (714273-83-3) + N,N'-diacetylpiperazin-2,5-dione (3027-05-2) → 1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione (714273-84-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield: 86.0%

1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione (714273-84-4) + 3-(azetidine-1-carbonyl)benzaldehyde → (3Z,6Z)-3-((azetidine-1-carbonyl)benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.03.005

upstream raw materials:

4-tert-butyl-1H-imidazole-5-carbaldehyde

N,N'-diacetylpiperazin-2,5-dione

5-(tert-butyl)-1H-imidazole-4-carbaldehyde

Downstream raw materials:

(3Z,6Z)-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)piperazine-2,5-dione

3-{(Z)-1-[5-(tert-Butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-cyclohexylmethylidene]-2,5-piperazinedione

3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-ethoxyphenyl)methylidene]-2,5-piperazinedione trifluoroacetate

3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(3-cyanophenyl)methylidene]-2,5-piperazinedione trifluoroacetate