ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

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Chemical Name:ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate
CAS No.:697304-78-2
Molecular Formula:C₂₆H₂₉FN₄O₄
Molecular Weight:480.539
Hs Code.:

Synonyms:ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

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Chemical Property of ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

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Technology Process of ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

There total 5 articles about ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 697305-50-3
1-(4-fluoro-2-methylphenyl)piperazin-2-one hydrochloride

: C₁₉H₂₁N₃O₆

: 697304-78-2
ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2017.09.031

Reference yield:

: 697306-96-0
ethyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate methanesulfonate

: 697304-78-2
ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1016/j.bmc.2017.09.031

Reference yield:

: 452-71-1
4-fluor-2-methylaniline

: 697304-78-2
ethyl (2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / Isopropyl acetate; water / 0 - 20 °C

2: Isopropyl acetate / 60 °C

3: tributylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran; toluene / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With tributylphosphine; di-tert-butyl-diazodicarboxylate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Isopropyl acetate; water; toluene; acetonitrile; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2017.09.031