4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester
• CAS No.: 155877-91-1
• Molecular Formula: C₂₃H₂₆N₂O₅
• Molecular Weight: 410.47

Synonyms:4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester

Chemical Property of 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester

There total 3 articles about 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid (103031-30-7) → 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester (155877-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / HNO₃, H₂SO₄ / 1 h / Ambient temperature

2: thionyl chloride / 2 h / 55 °C

3: pyridine / diethyl ether

With pyridine; thionyl chloride; sulfuric acid; nitric acid; In diethyl ether;

DOI:10.1021/jm00036a017

Reference yield:

5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-nitro-2-naphthoic acid (155877-89-7) → 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester (155877-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 55 °C

2: pyridine / diethyl ether

With pyridine; thionyl chloride; In diethyl ether;

DOI:10.1021/jm00036a017

Reference yield:

5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl chloride + 4-methoxycarbonyl aniline (619-45-4) → 4-[(5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid methyl ester (155877-91-1)

Guidance literature:

With pyridine; In diethyl ether; Yield given;

DOI:10.1021/jm00036a017

upstream raw materials:

4-methoxycarbonyl aniline

5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid

5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-nitro-2-naphthoic acid

Downstream raw materials:

methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester

methyl 4-<(3-amino)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

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