2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

Base Information

Chemical Name:2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole
CAS No.:929409-56-3
Molecular Formula:C₂₂H₁₆FN₃S₂
Molecular Weight:405.52
Hs Code.:

Synonyms:2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

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Chemical Property of 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

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Technology Process of 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

There total 4 articles about 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1019177-86-6
C₁₄H₁₂FN₃S₂

: 70-11-1
α-bromoacetophenone

: 929409-56-3
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1016/j.bmc.2014.11.029

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 929409-56-3
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Reflux

2.1: ethanol / 1 h / 80 °C

2.2: 4 h

3.1: ethanol / 5 h / 80 °C

In ethanol;
DOI:10.1016/j.bmcl.2012.05.091

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 929409-56-3
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Reflux

2.1: ethanol / 1 h / 80 °C

2.2: 4 h

3.1: ethanol / 5 h / 80 °C

In ethanol;
DOI:10.1016/j.bmcl.2012.05.091