tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate
CAS No.:894794-92-4
Molecular Formula:C₂₆H₃₄ClN₅O₄
Molecular Weight:516.04
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

There total 2 articles about tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium carbonate: aqueous potassium carbonate

: 894794-88-8
tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-7-[(dimethylamino)methyl]-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

: 74-88-4
methyl iodide

: 894794-92-4
tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

Guidance literature:: With triethylsilane; sodium hydroxide; methanesulfonic acid; In tetrahydrofuran; dichloromethane; water; acetone;

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 894794-92-4
tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-1,3,7-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate

Guidance literature:: tert-butyl {(3R)-1-[5-(2-chlorobenzyl)-7-[(dimethylamino)methyl]-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl]piperidin-3-yl}carbamate; With methyl iodide; In acetone; at 20 ℃;

With sodium hydroxide; water; In tetrahydrofuran; at 60 ℃; for 3h;

methanesulfonic acid; With triethylsilane; In dichloromethane; at 0 ℃; for 1h;