2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

Base Information

Chemical Name:2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol
CAS No.:258524-67-3
Molecular Formula:C₃₉H₃₈N₂O₉
Molecular Weight:678.739
Hs Code.:

Synonyms:2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

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Chemical Property of 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

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Technology Process of 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

There total 4 articles about 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 258524-62-8
2,5-anhydro-1-O-benzoyl-3-deoxy-3-(thymin-1-yl)-L-mannitol

: 258524-67-3
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

Guidance literature:: With pyridine; at 20 ℃; for 26h;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I

Reference yield:

: 98-88-4
benzoyl chloride

: 258524-67-3
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / pyridine / 28 h / 20 °C

2: 97 percent / H₂O; CF₃COOH / tetrahydrofuran / 26 h / Heating

3: 77 percent / pyridine / 26 h / 20 °C

With pyridine; water; trifluoroacetic acid; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I

Reference yield:

: 196596-85-7
2,5-anhdyro-4-deoxy-4-(thymin-1-yl)-L-mannofuranose dimethyl acetal

: 258524-67-3
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / pyridine / 28 h / 20 °C

2: 97 percent / H₂O; CF₃COOH / tetrahydrofuran / 26 h / Heating

3: 77 percent / pyridine / 26 h / 20 °C

With pyridine; water; trifluoroacetic acid; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I