2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

Base Information

Chemical Name:2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)
CAS No.:258524-72-0
Molecular Formula:C₄₈H₅₅N₄O₁₀P
Molecular Weight:878.959
Hs Code.:

Synonyms:2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

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Chemical Property of 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

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Technology Process of 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

There total 6 articles about 2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 258524-67-3
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol

: 258524-72-0
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 258524-72-0
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / pyridine / 26 h / 20 °C

2: 77 percent / (iPr)2EtN / tetrahydrofuran

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1: Etherification / 2: Substitution;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I

Reference yield:

: 98-88-4
benzoyl chloride

: 258524-72-0
2,5-anhydro-1-O-benzoyl-3-deoxy-5-O-(dimethoxytrityl)-3-(thymin-1-yl)-L-mannitol 4-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / 28 h / 20 °C

2: 97 percent / H₂O; CF₃COOH / tetrahydrofuran / 26 h / Heating

3: 77 percent / pyridine / 26 h / 20 °C

4: 77 percent / (iPr)2EtN / tetrahydrofuran

With pyridine; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification / 4: Substitution;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<2037::AID-HLCA2037>3.0.CO;2-I