(D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Base Information

• Chemical Name: (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid
• CAS No.: 934367-84-7
• Molecular Formula: C₁₂H₁₁NO₃S₂
• Molecular Weight: 281.356
• Mol file: 934367-84-7.mol

Synonyms:(D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Chemical Property of (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

There total 2 articles about (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

carbon disulfide (75-15-0,12122-00-8) + D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + sodium monochloroacetic acid (3926-62-3) → (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid (934367-84-7)

Guidance literature:

carbon disulfide; D-(R)-phenylalanine; With sodium hydroxide; In water; at 0 - 20 ℃;

sodium monochloroacetic acid; In water; at 20 ℃; for 2h;

With hydrogenchloride; trichlorophosphate; In water; at 75 ℃; for 4h;

DOI:10.1016/j.bmcl.2014.04.004

Reference yield:

C10H10NO2S2(1-) + sodium monochloroacetic acid (3926-62-3) → (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid (934367-84-7)

Guidance literature:

C₁₀H₁₀NO₂S₂^(1-); sodium monochloroacetic acid; In water; at 20 ℃; for 2h;

With hydrogenchloride; trichlorophosphate; In water; at 75 ℃; for 4h;

DOI:10.1016/j.bmcl.2018.01.031

Reference yield: 91.0%

C16H11FN2O (1152934-95-6) + (D)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid (934367-84-7) → C28H20FN3O3S2 (1416219-05-0)

Guidance literature:

With piperidine; acetic acid; In ethanol; at 40 - 50 ℃;

DOI:10.1016/j.ejmech.2012.10.012

upstream raw materials:

carbon disulfide

D-(R)-phenylalanine

sodium monochloroacetic acid

Downstream raw materials:

C₂₈H₂₀ClN₃O₃S₂

C₂₈H₁₉Cl₂N₃O₃S₂

C₃₀H₂₅N₃O₃S₂

C₂₉H₂₃N₃O₃S₂