ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

Base Information

Chemical Name:ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate
CAS No.:1301660-83-2
Molecular Formula:C₃₃H₃₂F₇N₃O₄
Molecular Weight:667.624
Hs Code.:

Synonyms:ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

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Chemical Property of ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

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Technology Process of ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

There total 8 articles about ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1301660-80-9
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoprolinate

: 74-88-4
methyl iodide

: 1301660-83-2
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

Guidance literature:: ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoprolinate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -30 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at -30 - 20 ℃; for 53h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-83-2
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 18 h / 110 °C

5.1: sodium hydroxide; water / methanol / 18 h / 20 °C

6.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / -30 °C

7.2: 53 h / -30 - 20 °C

With osmium(VIII) oxide; water; sodium ethanolate; sodium hydride; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;

Reference yield:

: 1263187-14-9
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl ester

: 1301660-83-2
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1-methyl-5-oxoprolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 140 °C / Microwave irradiation

2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 18 h / 110 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 °C

4.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / -30 °C

5.2: 53 h / -30 - 20 °C

With water; sodium ethanolate; sodium hydride; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;