methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Base Information

Chemical Name:methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
CAS No.:877267-61-3
Molecular Formula:C₂₅H₂₅NO₂
Molecular Weight:371.479
Hs Code.:

Synonyms:methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

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Chemical Property of methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

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Technology Process of methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

There total 4 articles about methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 1-allyl-3-cyclohexyl-2-(2-vinylphenyl)-1H-indole-6-carboxylate: 877271-37-9
methyl 1-allyl-3-cyclohexyl-2-(2-vinylphenyl)-1H-indole-6-carboxylate

: 877267-61-3
methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Guidance literature:: With Zhannan catalyst I; In dichloromethane; at 35 ℃; for 1h;
DOI:10.1055/s-0029-1217168

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 877267-61-3
methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; lithium chloride; In ethanol; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.03.067

Reference yield:

: 877271-27-7
methyl 3-cyclohexyl-2-(2-vinylphenyl)-1H-indole-6-carboxylate

: 877267-61-3
methyl 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.067