2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine
CAS No.:672343-22-5
Molecular Formula:C₂₆H₄₆NOPSSi
Molecular Weight:479.783
Hs Code.:

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

There total 6 articles about 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 16523-54-9
chlorodicyclohexylphosphane

: 854691-01-3
(tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine

: 672343-22-5
2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

Guidance literature:: (tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃;

chlorodicyclohexylphosphane; In diethyl ether; hexane; at -78 - 20 ℃;

With sulfur; In diethyl ether; hexane; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2005.03.111

Reference yield:

: 16523-54-9
chlorodicyclohexylphosphane

: 672343-22-5
2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

Guidance literature:: (tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 4h;

chlorodicyclohexylphosphane; In diethyl ether; hexane; at -78 - 20 ℃;

With water; sulfur; more than 3 stages;

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 672343-22-5
2-(tert-butyl-dimethyl-silanyloxy)-(1R)-[2-(dicyclohexyl-phosphinothioyl)-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / 4 h / -78 - 20 °C

2.2: diethyl ether; hexane / -78 - 20 °C

2.3: 0.660 g / sulfur / diethyl ether; hexane / 1 h / 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ol0362717