benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate

Base Information

• Chemical Name: benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate
• CAS No.: 68280-76-2
• Molecular Formula: C₂HF₃O₂*C₂₆H₃₃N₃O₅
• Molecular Weight: 581.589
• Mol file: 68280-76-2.mol

Synonyms:benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate

Chemical Property of benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate

There total 5 articles about benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl N6-((benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysyl-L-prolinate (68280-74-0) + trifluoroacetic acid (76-05-1) → benzyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate (68280-76-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2015.04.061

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → benzyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate (68280-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: tetrahydrofuran; dimethylformamide / -10 - 20 °C

3: CH₂Cl₂ / 2.5 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9701132

Reference yield:

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride (16652-71-4) → benzyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate (68280-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) DMF, 1 h

2: CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane;

DOI:10.1021/jm00170a012

upstream raw materials:

benzyl N⁶-((benzyloxy)carbonyl)-N²-(tert-butoxycarbonyl)-L-lysyl-L-prolinate

trifluoroacetic acid

Boc-Lys(Z)-OH

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

Downstream raw materials:

BocD(OBzl)K(Z)POBzl

BocDAsp(OBzl)Lys(Z)ProOBzl