Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Base Information

• Chemical Name: Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
• CAS No.: 76512-74-8
• Molecular Formula: C₃₇H₃₆ClN₂O₉P
• Molecular Weight: 719.128
• Mol file: 76512-74-8.mol

Synonyms:Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property of Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

There total 4 articles about Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pyridine (110-86-1) + Phosphorobromidic acid 4-chloro-phenyl ester methyl ester (76512-71-5) + 5'-O-monomethoxytritylthymidine (42926-80-7,52474-36-9,124680-51-9,132970-00-4) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (76512-74-8) + Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with pyridine (76512-80-6)

Guidance literature:

In benzene; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)71487-0

Reference yield: 4.0%

Phosphorobromidic acid 4-chloro-phenyl ester methyl ester (76512-71-5) + 5'-O-monomethoxytritylthymidine (42926-80-7,52474-36-9,124680-51-9,132970-00-4) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (76512-74-8) + Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with pyridine (76512-80-6)

Guidance literature:

In pyridine; benzene; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)71487-0

Reference yield:

Phosphorous acid 4-chloro-phenyl ester dimethyl ester (18352-27-7) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (76512-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂

2: 85 percent / benzene / 0.5 h / 20 °C

With bromine; In benzene;

DOI:10.1016/S0040-4039(00)71487-0

upstream raw materials:

pyridine

Phosphorobromidic acid 4-chloro-phenyl ester methyl ester

5'-O-monomethoxytritylthymidine

Phosphorous acid 4-chloro-phenyl ester dimethyl ester

Downstream raw materials:

Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine