Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine

Base Information

• Chemical Name: Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine
• CAS No.: 76512-77-1
• Molecular Formula: C₃H₉N*C₃₆H₃₄ClN₂O₉P
• Molecular Weight: 764.212
• Mol file: 76512-77-1.mol

Synonyms:

Chemical Property of Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine

There total 8 articles about Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine (76512-77-1)

Guidance literature:

Multi-step reaction with 4 steps

1: TMA

2: Br₂

3: 85 percent / benzene; pyridine / 0.5 h / 20 °C

4: C₆H₅SH / acetonitrile / 24 h / Ambient temperature

With tetramethylammonium; bromine; thiophenol; In pyridine; acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)71487-0

Reference yield:

Phosphorous acid 4-chloro-phenyl ester dimethyl ester (18352-27-7) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine (76512-77-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂

2: 85 percent / benzene / 0.5 h / 20 °C

3: C₆H₅SH / acetonitrile / Ambient temperature

With bromine; thiophenol; In acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)71487-0

Reference yield:

Phosphorobromidic acid 4-chloro-phenyl ester methyl ester (76512-71-5) → Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with trimethyl-amine (76512-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / benzene / 0.5 h / 20 °C

2: C₆H₅SH / acetonitrile / Ambient temperature

With thiophenol; In acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)71487-0

upstream raw materials:

Phosphoric acid 4-chloro-phenyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

trimethylamine

Phosphoric acid 4-chloro-phenyl ester ethyl ester (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

phosphorous acid 4-chloro-phenyl ester diethyl ester