2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

Base Information

Chemical Name:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid
CAS No.:625114-00-3
Molecular Formula:C₁₆H₁₉ClO₆S
Molecular Weight:374.842
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

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Chemical Property of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

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Technology Process of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

There total 13 articles about 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3-hydroxycyclopentyl)propionic acid

: 625114-00-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

Guidance literature:: With formic acid; dihydrogen peroxide; In water; at 25 ℃;

Reference yield:

: 2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3-hydroxycyclopentyl)propionic acid

: 64-18-6
formic acid

: 625114-00-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

Guidance literature:: With dihydrogen peroxide; In water; at 25 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jm3008689

Reference yield:

: 17733-22-1
2-chlorothioanisole

: 625114-00-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-formyloxy-cyclopentyl)propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / toluene / 1.5 h / 50 - 60 °C / Inert atmosphere

3.1: hydrazine hydrate; potassium hydroxide / 16 h / -50 - 100 °C / Inert atmosphere

4.1: potassium carbonate; pivaloyl chloride / acetone / 0.33 h / -10 - 20 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -45 - 0 °C / Inert atmosphere

5.2: 4 h / -45 - 25 °C / Inert atmosphere

6.1: sulfuric acid / water; 1,4-dioxane / 15 h / Inert atmosphere; Reflux

7.1: dihydrogen peroxide / water / 16 h / 25 °C / Inert atmosphere

With aluminum (III) chloride; n-butyllithium; sulfuric acid; water; dihydrogen peroxide; pivaloyl chloride; potassium carbonate; hydrazine hydrate; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; chloroform; water; acetone; toluene;
DOI:10.1021/jm3008689