(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Base Information

Chemical Name:(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone
CAS No.:130115-13-8
Molecular Formula:C₂₈H₂₉NO₅
Molecular Weight:459.542
Hs Code.:

Synonyms:(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

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Technology Process of (4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

There total 12 articles about (4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 130115-11-6
(2R,3S,4R)-3-Benzylamino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester

: 503-38-8
trichloromethyl chloroformate

: 130115-13-8
(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Guidance literature:: With pyridine; In dichloromethane; at 40 ℃; for 4.5h;
DOI:10.1016/S0040-4039(00)89018-8

Reference yield: 64.0%

: 130115-11-6
isopropyl (2R,3S,4R)-3-benzylamino-2-benzyloxy-4-hydroxybutyrate

: 503-38-8
trichloromethyl chloroformate

: 130115-13-8
(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Guidance literature:: With pyridine; In dichloromethane; at 40 ℃; for 4.5h;
DOI:10.1016/S0040-4020(01)88510-0

Reference yield:

: 20698-91-3
(R)-methyl mandelate

: 130115-13-8
(4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / imidazole / dimethylformamide / Ambient temperature

2: 82 percent / DIBAL / hexane; diethyl ether / 0.33 h / -78 °C

3: MgSO₄ / toluene / 1 h / 0 °C

4: Et₃N / CH₂Cl₂ / Ambient temperature

5: 86 percent / HCl gas / 1) 0 deg C, 2) 50 deg C, 3 h

6: 64 percent / pyridine / CH₂Cl₂ / 4.5 h / 40 °C

With pyridine; 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; magnesium sulfate; triethylamine; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)88510-0