4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Base Information

Chemical Name:4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine
CAS No.:468062-83-1
Molecular Formula:C₂₃H₂₁BrFN₅
Molecular Weight:466.356
Hs Code.:

Synonyms:4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Suppliers and Price of 4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

There total 8 articles about 4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 468062-75-1
[3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridin-6-yl]-methanol

: 468062-83-1
4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Guidance literature:: With phosphorus tribromide; In chloroform; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

: 468062-83-1
4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / phosphorus oxychloride / 72 h / 20 °C

2.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

3.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

4.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

5.1: sodium / 20 °C

5.2: 92 percent / ethanol / 18 h / 60 °C

6.1: 85 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 2 h / 20 °C

7.1: 40 percent / diisobutylaluminum hydride / CH₂Cl₂ / 1.5 h / -78 °C

8.1: 43 percent / phosphorus tribromide / CHCl₃ / 2 h / 20 °C

With manganese(IV) oxide; sodium ethanolate; sodium; phosphorus tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; acetone; 1.1: Vilsmeier-Haack formylation / 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 468062-76-2
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 468062-83-1
4-[6-(bromomethyl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

2.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

3.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

4.1: sodium / 20 °C

4.2: 92 percent / ethanol / 18 h / 60 °C

5.1: 85 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 2 h / 20 °C

6.1: 40 percent / diisobutylaluminum hydride / CH₂Cl₂ / 1.5 h / -78 °C

7.1: 43 percent / phosphorus tribromide / CHCl₃ / 2 h / 20 °C

With manganese(IV) oxide; sodium ethanolate; sodium; phosphorus tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; acetone; 1.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015