1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate
CAS No.:1311138-50-7
Molecular Formula:C₂₄H₃₃N₃O₅
Molecular Weight:443.543
Hs Code.:

Synonyms:1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

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Chemical Property of 1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

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Technology Process of 1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

There total 7 articles about 1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26782-71-8
D-tert-leucine

: 1311138-50-7
1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; methanol / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 - 50 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1311138-07-4
6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine

: 124655-17-0
(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

: 1311138-50-7
1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: (R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; Inert atmosphere;

Reference yield:

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 1311138-50-7
1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 - 50 °C / Inert atmosphere

With water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; iron; In tetrahydrofuran; N,N-dimethyl-formamide;