ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate

Base Information

• Chemical Name: ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate
• CAS No.: 187950-80-7
• Molecular Formula: C₂₀H₂₄O₂Si
• Molecular Weight: 325.487
• Mol file: 187950-80-7.mol

Synonyms:ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate

Chemical Property of ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate

There total 4 articles about ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

deuterio(dimethyl)phenylsilane (22034-19-1) + (E)-ethyl 2-diazo-4-phenylbut-3-enoate (126580-12-9) → ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate (187950-80-7)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(96)02285-X

Reference yield:

trans-styrylacetic acid (2243-53-0,59744-46-6,1914-58-5) → ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate (187950-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. H₂SO₄ / 3 h / Heating

2: ABSA, DBU / acetonitrile / 0.5 h / Ambient temperature

3: Rh₂(OAc)4 / CH₂Cl₂ / 0.33 h / Ambient temperature

With dirhodium tetraacetate; ABSA; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;

DOI:10.1021/jo961952j

Reference yield:

ethyl (E)-4-phenylbut-3-enoate (1205-84-1) → ethyl (E)-2-deuterio-2-(dimethylphenylsilyl)-4-phenylbut-3-enoate (187950-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ABSA, DBU / acetonitrile / 0.5 h / Ambient temperature

2: Rh₂(OAc)4 / CH₂Cl₂ / 0.33 h / Ambient temperature

With dirhodium tetraacetate; ABSA; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;

DOI:10.1021/jo961952j

upstream raw materials:

deuterio(dimethyl)phenylsilane

(E)-ethyl 2-diazo-4-phenylbut-3-enoate

trans-styrylacetic acid

ethyl (E)-4-phenylbut-3-enoate