ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

Base Information

Chemical Name:ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate
CAS No.:1272354-97-8
Molecular Formula:C₂₉H₂₆N₆O₄S
Molecular Weight:554.629
Hs Code.:

Synonyms:ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

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Chemical Property of ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

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Technology Process of ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

There total 8 articles about ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1272356-84-9
ethyl 2-(5-bromopyridine-3-sulfonamido)acetate

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272354-97-8
ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

Guidance literature:: ethyl 2-(5-bromopyridine-3-sulfonamido)acetate; With hexamethyldistannane; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 5h; Inert atmosphere;

2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine; In 1,4-dioxane; for 18h; Inert atmosphere; Reflux;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272354-97-8
ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

4.1: lithium chloride; hexamethyldistannane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

4.2: 18 h / Inert atmosphere; Reflux

With hexamethyldistannane; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; lithium chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272354-97-8
ethyl 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamido)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

6.1: lithium chloride; hexamethyldistannane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

6.2: 18 h / Inert atmosphere; Reflux

With dihydrogen peroxide; hexamethyldistannane; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; lithium chloride; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;