2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

Base Information

Chemical Name:2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide
CAS No.:1448039-38-0
Molecular Formula:C₂₁H₂₂FNO₄S₂
Molecular Weight:435.54
Hs Code.:

Synonyms:2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

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Chemical Property of 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

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Technology Process of 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

There total 8 articles about 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448039-05-1
5-bromo-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

: 1448039-38-0
2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 2.5h;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 1448039-38-0
2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.25 h / -50 - -20 °C

1.2: -40 - 20 °C

2.1: trifluoroacetic acid / chloroform / 18 h / 0 - 50 °C

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / 0 °C

3.2: 3 h / 5 - 20 °C

4.1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C

5.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C

6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2.5 h / 20 °C

With palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; urea hydrogen peroxide adduct; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; n-heptane; chloroform; ethylbenzene; 1,2-dichloro-ethane; acetonitrile; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 2.1: |Fischer Indole Synthesis;

Reference yield:

: 1448038-85-4
5-bromo-2-cyclopropyl-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]

: 1448039-38-0
2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C

2: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; urea hydrogen peroxide adduct; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;