(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

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Chemical Name:(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid
CAS No.:1017260-44-4
Molecular Formula:C₃₀H₂₀N₂O₂S₂
Molecular Weight:504.633
Hs Code.:

Synonyms:(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

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Chemical Property of (E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

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Technology Process of (E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

There total 6 articles about (E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 762269-61-4
5′-(4-(diphenylamino)phenyl)(2,2′-bithiophene)-5-carboxaldehyde

: 372-09-8
cyanoacetic acid

: 1017260-44-4
(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

Guidance literature:: With ammonium acetate; acetic acid; at 120 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2009.04.024

Reference yield: 69.0%

: 1017260-44-4
(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

Guidance literature:

Reference yield:

: 4805-22-5
5,5'-dibromo-2,2'-bisthiophene

: 1017260-44-4
(E)-2-cyano-3-(5'-(5''-(p-(diphenylamino)phenyl)thiophen-2''-yl)thiophen-2'-yl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate; n-butyllithium / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling; Schlenk technique

1.2: 50 °C / Inert atmosphere; Cooling; Schlenk technique

2.1: toluene-4-sulfonic acid / benzene / 5 h / Inert atmosphere; Reflux; Schlenk technique

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique

3.2: Inert atmosphere; Schlenk technique

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux; Schlenk technique

5.1: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 12 h / 110 °C / Inert atmosphere; Schlenk technique

6.1: trifluoroacetic acid / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique

7.1: piperidine / acetonitrile / 6 h / Inert atmosphere; Reflux; Schlenk technique

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; hexane; water; acetonitrile; benzene; 4.1: |Suzuki Coupling / 5.1: |Buchwald-Hartwig Coupling / 7.1: |Knoevenagel Condensation;
DOI:10.1002/chem.201201500