5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS No.: 174314-52-4
• Molecular Formula: C₉H₁₀N₂S
• Molecular Weight: 178.258
• Mol file: 174314-52-4.mol

Synonyms:5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property of 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

There total 2 articles about 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Cyanothioacetamide (7357-70-2) + 3-hydroxymethylene-2-pentanone sodium salt (143745-99-7) → 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (174314-52-4)

Guidance literature:

With acetic acid; In ethanol; Heating;

DOI:10.1007/BF01169072

Reference yield:

Cyanothioacetamide (7357-70-2) + 2-Pentanone (107-87-9) + formic acid ethyl ester (109-94-4) → 6-Propyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (101045-95-8) + 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (174314-52-4)

Guidance literature:

With sodium ethanolate; acetic acid; Yield given. Multistep reaction; 1.) ether, RT, 3 h, 2.) C₂H₅OH, reflux;

DOI:10.1007/BF01169072

Reference yield: 71.0%

methyl chloroacetate (96-34-4) + 5-Ethyl-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (174314-52-4) → (3-Cyano-5-ethyl-6-methyl-pyridin-2-ylsulfanyl)-acetic acid methyl ester

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; for 0.5h;

DOI:10.1007/BF01169072

upstream raw materials:

Cyanothioacetamide

3-hydroxymethylene-2-pentanone sodium salt

2-Pentanone

formic acid ethyl ester