[1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal

Base Information

• Chemical Name: [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal
• CAS No.: 392690-94-7
• Molecular Formula: C₁₄H₂₀FNO₄S
• Molecular Weight: 317.382
• Mol file: 392690-94-7.mol

Synonyms:[1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal

Chemical Property of [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal

There total 1 articles about [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 4-formylpiperidine dimethyl acetal → [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal (392690-94-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/S0960-894X(02)00608-X

Reference yield: 20.0%

methyl pyrazole-4-carboxylate (51105-90-9,54866-59-0) + [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal (392690-94-7) → 1-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-1H-pyrazole-4-carboxylic acid methyl ester (571146-13-9)

Guidance literature:

With potassium hydride; In N,N-dimethyl-formamide; at 118 ℃; for 18h;

DOI:10.1016/S0960-894X(02)00608-X

Reference yield:

methyl 1H-indole-4-carboxylate (39830-66-5) + [1-(4-fluorobenzenesulfonyl)-piperidin-4-yl]-carboxaldehyde dimethyl acetal (392690-94-7) → [1-(4-{4-Ethoxycarbonylindol-1-yl}-benzenesulfonyl)-piperidin-4-yl]-carboxaldehyde Dimethylacetal

Guidance literature:

In hexane; N,N-dimethyl-formamide;

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

Downstream raw materials:

1-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-1H-pyrazole-4-carboxylic acid methyl ester

[1-(4-{4-Ethoxycarbonylpyrazol-1yl}-benzenesulfonyl)-piperidin-4-yl]-carboxaldehyde

[1-(4-{2-Ethoxycarbonylindol-1yl}-benzenesulfonyl)-piperidin-4-yl]-carboxaldehyde