benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate
• CAS No.: 955936-51-3
• Molecular Formula: C₂₃H₃₀N₂O₆
• Molecular Weight: 430.501
• Mol file: 955936-51-3.mol

Synonyms:benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate

Chemical Property of benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate

There total 2 articles about benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-47-7) + methyl 2-(bromomethyl)propenoate (4224-69-5) → benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-51-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 23 ℃;

DOI:10.1016/j.tet.2007.07.083

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: BF₃*Et₂O / CH₂Cl₂ / 9 h / 0 - 23 °C

2: 65 percent / NaH / tetrahydrofuran; dimethylformamide / 0 - 23 °C

With boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.07.083

Reference yield: 90.0%

benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-51-3) → 1,3-dimethyl 9-benzyl 1,9-diazaspiro[5.5]undec-3-ene-1,3,9-tricarboxylate (955936-55-7)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 4h; Heating;

DOI:10.1016/j.tet.2007.07.083

upstream raw materials:

benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate

methyl 2-(bromomethyl)propenoate

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

1,3-dimethyl 9-benzyl 1,9-diazaspiro[5.5]undec-3-ene-1,3,9-tricarboxylate