benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate

Base Information

• Chemical Name: benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate
• CAS No.: 955936-47-7
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4
• Mol file: 955936-47-7.mol

Synonyms:benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate

Chemical Property of benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate

There total 1 articles about benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + methyl carbamate (598-55-0) + allyl-trimethyl-silane (762-72-1) → benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-47-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 23 ℃; for 9h;

DOI:10.1016/j.tet.2007.07.083

Reference yield: 65.0%

benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-47-7) + methyl 2-(bromomethyl)propenoate (4224-69-5) → benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-51-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 23 ℃;

DOI:10.1016/j.tet.2007.07.083

Reference yield:

benzyl 4-{[(methyloxy)carbonyl]amino}-4-prop-2-en-1-ylpiperidine-1-carboxylate (955936-47-7) → 1,3-dimethyl 9-benzyl 1,9-diazaspiro[5.5]undec-3-ene-1,3,9-tricarboxylate (955936-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaH / tetrahydrofuran; dimethylformamide / 0 - 23 °C

2: 90 percent / second generation Grubbs catalyst / CH₂Cl₂ / 4 h / Heating

With sodium hydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.07.083

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

methyl carbamate

allyl-trimethyl-silane

Downstream raw materials:

benzyl 4-([(methyloxy)carbonyl]{2-[(methyloxy)carbonyl]prop-2-en-1-yl}amino)-4-prop-2-en-1-ylpiperidine-1-carboxylate

1,3-dimethyl 9-benzyl 1,9-diazaspiro[5.5]undec-3-ene-1,3,9-tricarboxylate