methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

Base Information

Chemical Name:methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside
CAS No.:342789-74-6
Molecular Formula:C₃₆H₅₀O₈Si
Molecular Weight:638.874
Hs Code.:

Synonyms:methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

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Chemical Property of methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

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Technology Process of methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

There total 6 articles about methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 100-39-0
benzyl bromide

: 342789-73-5
methyl 3,4-di-O-(4-methoxybenzyl)-6-O-tert-butyldimethylsilyl-α-D-glucopyranoside

: 342789-74-6
methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1021/jo001575h

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 342789-74-6
methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: TfOH / diethyl ether / 1 h / 20 °C

2: 155.7 mg / NaOH / H₂O / 0.5 h / 20 °C

3: 94 percent / imidazole / dimethylformamide / 0.5 h / 20 °C

4: 81.1 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; sodium hydroxide; trifluorormethanesulfonic acid; sodium hydride; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001575h

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 342789-74-6
methyl 6-O-tert-butyldimethylsilyl-2-O-benzyl-3,4-di-O-methoxybenzyl-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / imidazole / dimethylformamide / 0.5 h / 20 °C

2: 81.1 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo001575h