2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

Base Information

Chemical Name:2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide
CAS No.:1449030-00-5
Molecular Formula:C₃₃H₃₁ClN₂O₄
Molecular Weight:555.073
Hs Code.:

Synonyms:2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

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Chemical Property of 2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

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Technology Process of 2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

There total 5 articles about 2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2398-05-2
4-Oxo-6-phenyl-4H-pyran-2-carbaldehyde

: 931-53-3
Cyclohexyl isocyanide

: 106-49-0,12221-03-3
p-toluidine

: 118-91-2
ortho-chlorobenzoic acid

: 1449030-00-5
2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

Guidance literature:: 4-Oxo-6-phenyl-4H-pyran-2-carbaldehyde; p-toluidine; In methanol; at 20 ℃; for 0.5h;

Cyclohexyl isocyanide; ortho-chlorobenzoic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2013.05.049

Reference yield:

: 76782-46-2
ethyl 6-phenyl-2,4,6-trioxohexanoate

: 1449030-00-5
2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 4 h / Reflux

3.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 24 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sulfuric acid; In methanol; dichloromethane; 4.1: |Ugi Condensation / 4.2: |Ugi Condensation;
DOI:10.1016/j.ejmech.2013.05.049

Reference yield:

: 93-91-4
1-phenylbutan-1,3-dione

: 1449030-00-5
2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2-dimethoxyethane / 4 h / Reflux

2.1: sulfuric acid / 4 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 4 h / Reflux

4.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C

5.1: methanol / 0.5 h / 20 °C

5.2: 24 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sulfuric acid; In methanol; 1,2-dimethoxyethane; dichloromethane; 5.1: |Ugi Condensation / 5.2: |Ugi Condensation;
DOI:10.1016/j.ejmech.2013.05.049