76782-46-2

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 1449030-00-5 2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-p-tolylbenzamide 
• 1449030-01-6 N-[(tert-butylcarbamoyl)(4-oxo-6-phenyl-4H-pyran-2-yl)methyl]-N-p-tolylbenzamide 
• 1449030-02-7 2-chloro-N-[(cyclohexylcarbamoyl)(4-oxo-6-phenyl-4Hpyran-2-yl)methyl]-N-(4-methoxyphenyl)benzamide 
• 1449030-03-8 N-[(tert-butylcarbamoyl)(4-oxo-6-phenyl-4H-pyran-2-yl)methyl]-2-chloro-N-(4-methoxyphenyl)benzamide 
• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 230617-82-0 4-Hydroxymethyl-6-phenyl-4H-pyran-2-one 
• 2398-05-2 4-Oxo-6-phenyl-4H-pyran-2-carbaldehyde 

Relevant academic research and scientific papers

Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction

Fourteen novel bis-carboxamide derivatives of 4-pyrones were designed and synthesized via Ugi four-component reactions of 4-pyrone carbaldehydes, aromatic amines, isocyanides and carboxylic acids. The cytotoxic activity of synthesized derivatives was eval

6-Substituted pyranone compounds and their use as pharmaceuticals

Compounds are described of the formula STR1 in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or R6, where R5 is hydrogen or C1-8 alkyl and R6 is phenyl or naphthyl, the phenyl or naphthyl group being optionally substituted by one or more group selected from halogen, C1-6 alkyl, C1-4 alkoxy, hydroxy, benzyloxy, nitro, trifluoromethyl, carboxyl, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, N(R5)2, NHCOR5 and SR5 ; R2 is R6 or --CH=CH--R6 when R1 is COOR5, CONHR5, cyano or 5-tetrazolyl, or R2 is --CH=CH--R6 when R1 is R6 ; R3 is hydrogen, C1-6 alkyl, halogen, hydroxy or --OCH2 R6 ; and R4 is hydrogen, C1-6 alkyl or halogen; and salts thereof. The compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.